Processes, Sustainable Chemistry and Health

The staff

Director: GHINET Alina

Name – Title – Laboratory
Christophe ANDRE – HDR- PIHM-INRA
Alina GHINET – HDR – Lille 2 – INSERM U995
Laurent PEYRODIE – HDR – UTSB-LAGIS
Benoît RIGO – HDR – Lille 2 – INSERM U995
Karim BELHARET – EC – PRISME (HEI Campus Centre)
Pascale BOUVIER – EC – Energétique Industrielle EMDouai
Hua CAO – EC – UTSB
Philippe GAUTRET – EC – Lille 2 – INSERM U995
Jules Voguelin SIMO TALA – EC – Energétique Industrielle EMDouai
Mouna SOUISSI – EC – PRISME  (HEI Campus Centre)

Pierrick DUFRENOY – Postdoctoral researcher – Université du Havre – INSERM LIRIC UMR 995

Germain HOMERIN – Postdoctoral researcher – INSERM U995

Bineet MEHRA – Postdoctoral researcher – Energétique Industrielle EMDouai
Lyes MELLAL Postdoctoral researcher – Université d’Orléans – PRISME (HEI Campus Centre)

Iuliana-Monica MOISE – Postdoctoral researcher –”Al. I. Cuza” University, Iasi, Romania
Sawsen ZOUAGHI – Postdoctoral researcher – Université de Lille 1 – UMET
Walid AMOKRANE – Postdoctoral researcher – PRISME (HEI Campus Centre)

Themes

Scientific              

Energy processes : Heat transfer, Transfer of matter, fluid mechanics
Reactional mechanics, structure-activity relations (QSAR), route signalling actions
Signal processing

 

Technical

Modelling, simulation, experimentation
Synthesis/analysis in organic chemistry
Data analysis

 

Fields of application

Energy processes : Food industry (cleaning equipment), aeronautics, rail, automobile

Housing (heat recovery, heating, cooling, etc.)
Chemical industry, pharmaceuticals (medicines, etc.)
Medical (biological models, exoskeleton, etc.)

The Processes, Sustainable Chemistry and Health unit (PCDS) is made up of three research teams (‘energy processes’ team, ‘organic chemistry’ team and ‘signal processing’ team) with complementary research fields.

The issues currently dealt with by the ‘energy processes’ team are linked to understanding how heat exchangers can become clogged up and to studying mixing and agitation systems. Assessments of mixing and agitation, digital and experimental fluid mechanics, convective transfers, thermodynamic optimisation (entropic and synergetic analysis) and the intensification of convective exchanges through the modification of runoff help increase the energy efficiency of processes. The development of these new optimised processes is enhanced through partnerships with the industrial sector.

The ‘organic chemistry’ team has internationally recognised expertise in the field of pyroglutamic acid chemistry, which they use as a basic synthon for a large number of types of heterocyclic compounds. The discovery of new reaction mechanisms often leads to optimised processes, enabling syntheses to be made in large quantities – a vital consideration in work with industrial companies, in particular.
HEI’s ‘organic chemistry’ team has joined an INSERM team (U995 – Therapeutic Innovation Targeting Inflammation), bringing us greater exposure internationally. This ‘multi-unit’ team, supported by the Université de Lille 2, the CHRU, INSERM and HEI, perfectly matches national policies and their definition of social issues. The team will concentrate its activities on chronic inflammatory diseases, considered as new social challenges in terms of health. In this respect, the HEI team is putting forward new therapeutic strategies to treat and prevent inflammatory difficulties.

Energy processes

Expertise

SCIENTIFIC :

  • Agitation – mixing
  • Modelling of phenomena of transfer of matter
  • Dimensional analysis
  • Digital and experimental fluid mechanics, heat transfer, thermodynamic optimisation
  • Entropic and synergetic analysis
  • Intensification of convective exchanges through modifying flows

TECHNICAL :

  • DTS software (modelling of runoff by passive tracing)
  • Velocimetry by imagery of particles PIV 2D2C, LDA/LDV
  • CFD tools: Star CCM+, FLUENT, TRNSYS
  • Digital treatment of data: MATLAB

APPLICATIONS :

  • Food industry
  • Cleaning equipment
  • Improvement of performances and systematic enhancement of industrial heat exchangers
  • Recuperation and repurposing of thermal waste
  • Energy efficiency of industrial thermal components

Projects

Diapositive1Diapositive2

Organic chemistry

Expertise

SCIENTIFIC:

  • Pyroglutamic acid chemistry
  • Organometallic synthesis
  • Heterocyclic chemistry
  • Drug design
  • QSAR (Quantitative structure–activity relationship)
  • Reactional mechanics
  • N-acyliminium ions

TECHNICAL:

  • Organic synthesis: synthesis under inert atmosphere: large-scale synthesis, multi-stage synthesis
  • Spectroscopic, analytic: Multinuclei NMR (1H, 13C, 19F, 31P), Flash LC, LC-MS, GC-MS, IR

APPLICATIONS:

  • Organic chemistry
  • Medicinal chemistry
  • Fine chemistry
  • Detergents, cosmetics, treatment of metals, etc.

 

Main projects

  • OPTISTIM Project

“Optimisation of the efficiency of Plant Defence Inducers (PDIs)

biosourced for an alternative crop protection method” – Partners: HEI, ISA, ULCO

  • ECO-CATALYSTS Project

“Development of heterogeneous regenerating catalysts from plants grown in contaminated soil for repurposing in organic synthesis” – Partners: HEI, ISA, Université du Havre

  • P2X7R Project

“Deciphering tumour suppressor role of P2RX7 receptor and its evaluation as a new drug-target in inflammation-associated carcinogenesis” – Funded by InCa

Partners: HEI, ICPAL, Université Nice Sophia Antipolis, Université de Rouen

  • “Anti-cancer compounds” Project

Partners: HEI, “Al. I. Cuza” University, Iasi, Romania

  • “Anti-fungus and anti-microbe compounds” Project

Partners: HEI, University of Queensland

Biomedical engineering

Expertise

SCIENTIFIC :

  • Nonlinear analysis of physiological signal
  • Decision theory
  • Assessment methodologies
  • Medical imaging, signal processing and the image in biomedicine
  • Mechatronics: Mechanics, electronics, automatic control, information technology
  • Robotics
  • Multi-scale modelling, multi-physical simulation, control and observation of linear and nonlinear systems.

TECHNICAL :

  • RQA method (Recurrence Quantification Analysis)
  • SCM (Support Centre Machine)
  • Analytics: MATLAB simulation, multi-physical simulation with COMSOL.
  • Micro/nano manipulation with and without contact, design of actuator for micro/nano handling.
  • Humanoid robot control, mobile robots on wheels; mechanic modelling

APPLICATIONS :

Medical field: analysis of electrophysiological signals, diagnosis aid, development of robotic platforms for therapeutic targeting of cancers, injection and delivery of medicines, analysis of biological samples.

MANAGERIAL :

Biomedical Signal Processing Department Unit, collecting data for clinical trial dossiers

Experimental and software platforms

The laboratory in pictures